Perturb-multiome
CRISPR perturbation × single-cell gene expression and chromatin accessibility.
Research
From perturbation
to mechanism.
My research connects technology development, cardiovascular biology, and predictive computation.
Research logic
Build causal measurements. Discover regulatory mechanisms. Predict the next intervention.
01
Perturbation Omics Technologies
Make cellular causality measurable.
Experimental platforms that pair programmed perturbations with transcriptomic, epigenomic, and spatial phenotypes.
- Perturb-seq
- Perturb-multiome
- Perturb-spatial
Research rationale
Single-cell atlases reveal biological heterogeneity but are primarily observational. Perturbation omics moves from association to mechanism by measuring controlled interventions across thousands of individual cells.
The long-term goal is a unified platform that progresses from pooled discovery to multimodal mechanism and spatial validation.
02
Cardiovascular Functional Genomics
Resolve the regulatory logic of the heart.
Causal maps of the programs that govern cardiac maturation, maladaptive remodeling, and regenerative potential.
- Cardiac maturation
- Heart failure
- Regeneration
Research rationale
Cardiovascular development and disease involve coordinated changes across cardiomyocytes, fibroblasts, vascular cells, immune cells, and other populations.
My future program will connect human genetics, physiological models, multi-omic measurements, and perturbation screens to experimentally testable mechanisms.
03
AI-enabled Biology
Let experiments train the model.
Interpretable computational systems that predict cellular responses and guide more informative experiments.
- Perturbation prediction
- Computational frameworks
- AI agents for biology
Research rationale
Perturbation datasets contain defined interventions and therefore provide an unusually strong foundation for biological prediction.
Models will be evaluated by whether they identify mechanisms, generalize across contexts, and prioritize experiments that produce new knowledge.
Current projects
Work in progress
Public descriptions remain deliberately concise while studies are ongoing.
Visium HD Perturb-spatial
Spatial response fields and local tissue effects of perturbation.
In vivo Perturb-seq
Programmable gene regulation in cardiovascular models.
Cardiac maturation snATAC atlas
Chromatin dynamics across postnatal cardiac maturation.