Xiangjie ZhaoUNC Chapel Hill

Xiangjie Zhao, PhD · UNC Chapel Hill

Perturbation genomics for the developing and diseased heart.

Developing perturbation-enabled single-cell and spatial multi-omics technologies to study cardiovascular development and disease.

Xiangjie Zhao
Postdoctoral Research Associate
Pathology & Laboratory Medicine

Research program

Three connected directions

Technology, mechanism, and prediction form a single experimental cycle.

01

Perturbation Omics Technologies

Single-cell, multi-omic, and spatial readouts of genetic perturbation.

Perturb-seq · Multiome · Spatial ↗ 02

Cardiovascular Functional Genomics

Causal regulatory programs in maturation, failure, and regeneration.

Development · Disease · Repair ↗ 03

AI-enabled Biology

Models that predict perturbation response and inform experiment design.

Predict · Integrate · Design ↗

Research in view

Experiments, tissues, cell states

IMPACT-seq experimental workflow from AAV delivery to multi-omic sequencing and in vivo validation
01IMPACT-seq experimental workflow
Cell segmentation across a cardiac tissue section
02Cardiac tissue cell segmentation
Single-nucleus ATAC-seq embedding of cardiac cell types and developmental time points
03Cardiac maturation snATAC landscape

Research infrastructure

Resources for the field

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Pre-publication resource

Cardiac Maturation snATAC Atlas

Cell-type-resolved regulatory landscapes across postnatal maturation.

Launch atlas ↗ Published

HOHC

Human organ hormonal communication and receptor biology.

Database / Web

Selected publications

Recent work

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2025

A systematic analysis of human hormone receptors.

Zhao X, Wang XJ · Science China Life Sciences

DOI ↗
2022

A multi-axis robot-based bioprinting system supporting cardiac tissue fabrication.

Zhang Z, Wu C, Dai C, et al. · Bioactive Materials

DOI ↗