Xiangjie Zhao, PhD · UNC Chapel Hill
Perturbation genomics for the developing and diseased heart.
I build single-cell, multi-omic, and spatial technologies that measure what happens when you actually change a gene — and models that learn from the answer.
Open to collaborations
Research program
Three directions,
one experimental cycle.
Perturbation Omics Technologies
Experimental platforms that pair programmed perturbations with transcriptomic, epigenomic, and spatial phenotypes.
Perturb-seq · Multiome · Spatial 02 /Cardiovascular Functional Genomics
Causal maps of the programs that govern cardiac maturation, maladaptive remodeling, and regenerative potential.
Development · Disease · Repair 03 /AI-enabled Biology
Interpretable computational systems that predict cellular responses and guide more informative experiments.
Predict · Integrate · DesignResearch in view
Cell states across
cardiac maturation.
The chromatin landscape of postnatal cardiac maturation, from the public atlas. Figures from unpublished studies stay off the page until the work is out.
Research infrastructure
Resources for the field.
Selected publications
Recent work.
A systematic analysis of human hormone receptors
Zhao X, Wang XJ · Science China Life Sciences
A multi-axis robot-based bioprinting system supporting natural cell function preservation and cardiac tissue fabrication
Zhang Z, Wu C, Dai C, Shi Q, Fang G, Xie D, Zhao X, Liu YJ, Wang CCL, Wang XJ · Bioactive Materials
Collaboration